Ketone signaling refers to the mechanisms by which ketone bodies, such as beta-hydroxybutyrate (BHB), acetoacetate, and acetone, act as signaling molecules in various physiological processes. Ketone bodies are primarily produced during periods of fasting, prolonged exercise, or adherence to a ketogenic diet, and are known to have various signaling functions in the body. Research in this area has shown that ketone bodies can act as signaling molecules that regulate metabolism, inflammation, oxidative stress, and cellular energy production. Ketone signaling has also been implicated in the regulation of gene expression, cell survival, and neuroprotection. Studies have suggested that ketone bodies can have beneficial effects on various health conditions, such as neurodegenerative diseases, metabolic disorders, and cardiovascular diseases. Understanding the mechanisms of ketone signaling may lead to the development of new therapeutic strategies for treating these conditions. Overall, research in the field of ketone signaling aims to uncover the complex signaling pathways and mechanisms by which ketone bodies exert their effects in the body, and to explore the potential therapeutic applications of targeting these pathways.